Marine Toxins That Target Voltage-gated Sodium Channels
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چکیده
منابع مشابه
Marine Toxins That Target Voltage-gated Sodium Channels
Eukaryotic, voltage-gated sodium (NaV) channels are large membrane proteins which underlie generation and propagation of rapid electrical signals in nerve, muscle and heart. Nine different NaV receptor sites, for natural ligands and/or drugs, have been identified, based on functional analyses and site-directed mutagenesis. In the marine ecosystem, numerous toxins have evolved to disrupt NaV cha...
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Antiepileptic drugs (AEDs) protect against seizures through interactions with a variety of cellular targets. By affecting the functional activity of these targets, AEDs suppress abnormal hypersynchronous activity in brain circuits, leading to protection against seizures. The actions on these targets can be categorized into four broad groups: (i) modulation of voltage-gated ion channels, includi...
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ژورنال
عنوان ژورنال: Marine Drugs
سال: 2006
ISSN: 1660-3397
DOI: 10.3390/md403157